|
DEOXO-FLUOR™ FLUORINATING REAGENT
The Deoxo-Fluor™ reagent is a versatile, easy-to-use, nucleophilic fluorinating reagent with enhanced safety features. It rapidly
"deoxofluorinates" a wide variety of alcohols, aldehydes, and ketones under mild conditions to yield the corresponding fluorinated compounds with high efficiency and selectivity. Deoxo-Fluor reagent is thermally less sensitive than DAST, the traditional
deoxofluorinating agent and is thus more amenable to large-scale use. See Summary of Applications and Thermal Stability Data.
Deoxo-Fluor reagent is packaged in convenient
quantities for R&D evaluation and commercial manufacturing.
Technical assistance is available to provide a solution
to your fluorination challenge. Call 800-233-4334
to review your process with our fluorination experts.
Bis-(2-methoxyethyl)aminosulfur Trifluoride
 |
|
- Highly selective
- Cost efficient
- Easy to use; enhanced safety
- Stable liquid
- Converts C-O to C-F
|
Summary of Properties and Special Features
Physical Properties
| • Molecular Formula |
 |
C6H14F3NO2S |
| • Molecular Weight |
| 221.23 g/mol |
| • Appearance |
|
Dark yellow liquid at room tempature |
| • Melting Point |
|
Not determined |
| • Boiling Point |
|
Dec. |
| • Flash Point |
|
No flash observed up to 100°C |
| • Density |
| 1.2 g/mL |
Chemical Properties
| • Reactivity |
|
Alcohols, aldehydes and ketones; reacts violently with H2O to form HF |
| • Activity for c-oh |
|
85.9 g of active F/Kg or 4.5 mmol of F/g of Deoxo-Fluor reagent |
| • Activity for c-o |
|
171.8g of F/Kg or 9.0 mmol of F/G of Deoxo-Fluor reagent |
| • Purity |
| >95% F-Active |
| • Solubility |
|
Hexane, ethers, halogenated organics, toluene, and other
organic solvents |
| • Compatibility |
|
Stainless steel, Hastelloy®, Monel®, PTFE, HDPE; glass not recommended |
| • Stability |
| Stable at room temperature in the absence of moisture |
| • Decomposition |
| >95°C by ARC |
Safety Precautions
| • Storage |
|
For long-term storage, refrigerate and store under nitrogen |
| • Handling |
| Work in an inert, anhydrous atmosphere |
| • Precautions |
| Harmful if swallowed, inhaled, or absorbed through the skin |
| • First Aid Measures |
| Flush eyes and skin with copious amounts of water for at least 15 minutes.Contact a physician. |
Deoxo Fluor™ is a trademark of Air Products and Chemicals, Inc.
Summary of Fluorination Applications of Deoxo-Fluor™ Reagent
More examples:
Comparison of the Thermal Stability of Deoxo-Fluor and DAST Reagents
Click here to view document (PDF, 11K)
Deoxo-fluor Flourinating Reagents Datasheet (PDF)
Material Safety Data Sheets
Note: The information is in PDF format. You will need the free Adobe Acrobat Reader to view this information.
References
- G. S. Lal, G. P. Pez, R. J. Pesaresi and F. M. Prozonic, Chem. Commun., 1999, 215
- G. S. Lal, G. P. Pez, R. J. Pesaresi. F. M. Prozonic and H. Cheng, J. Org. Chem., 1999, 64, 7048
- G. S. Lal, E. Lobach and A. Evans, J. Org. Chem., 2000, 65, 4830
- R. P. Singh, B. Twamley and J. M. Shreeve, J. Org. Chem., 2002, 67, 1918
- For a comprehensive review, see R. P. Singh and J. M. Shreeve, Synthesis, 2002, 2561.
Scott Medical Products also offers Air Product's Selectfluor fluorinating reagent. |
